Dr. Jacques-Louis Binet is the founder of the Binet Clinical Staging System for CLL, published in 1977 and revised in 1981. In 1980, the Société Française d’Hématologie formed a cooperative group on CLL, which eventually produced the definite chlorambucil study comparing treatment and no treatment, setting the stage for Watch and Wait management of today’s Binet Stage A or Rai Stage 0 / I disease.